I'm on 125mcg have been taking it for about 15 years. I don't find it a miracle cure, I still have periods of feeling sluggish. Although I can remember how bad I felt before I was diagnosed with an under active thyroid, not something I had heard of or was familiar with.
I try to counter act my lethargy by walking, hence my posts on the 10,000 steps a day forum. My energy levels fluctuate a lot I'm never quite sure why, although I feel worse eating bread, even though I love it.
I was on a much higher dose of thyroxine a few years ago, but have cut back as I hear it depletes bone density and my mother had osteoporosis (only in the last six of seven years of her life) but I think I might also have a propensity to that condition. I was prescribed calcium tablets a while back but found out that these also compromise the absorption of the thyroxine. In addition a while ago there was a report to suggest that calcium tablets are not good for the heart, insomuch as they deposit calcium in the arteries. Typically their were counter arguments against that theory. I don't know what to believe but I stopped taking them anyway and do load bearing exercises at the gym, allegedly good for strengthening the bones.... when I can be bothered !