ruby yes we have a macerator, because we only use the upstairs occasionally it isn’t a problem, it’s nearly 20 yrs old now, if the upstairs rooms were used on a regular basis, we would now get a ‘Proper’ loo, I have a notice pinned to the wall warning people not to flush anything other than paper down there, apart from the obvious of course, it’s quite a funny note ( from Pinterest) .
It does make a brief noise when it flushes or when the washbasin is emptied( if it fills the container.) but it never bothered the Grandchildren.
The loo is directly above the bathroom, we just didn’t have enough of a fall for the out pipe, it’s in the eaves really so we couldn’t raise the height to get the fall.
The only downside is that the fan in the bathroom can be heard in one of the bedrooms , as it’s directly above the shower.
We also used the dead spaces in the eaves to put chests of drawers in and plaster boarded around it, so no lost space there.
All the windows are ‘means of escape windows’