Yes! My Mother was estranged from her Mother as a child.
I know that it doesn't seem possible now but her Father was an alcoholic and her Mother tried to leave with her but his family stepped in and wouldn't let her.
Consequently, she was raised by her Great Aunt, who twisted her mind regarding her Mother and told her she had been abandoned.
She took pleasure in telling me that she often saw a woman watching her in the street and knew it was her Mother but ignored her.
I know that when my Sister and myself were small, presents and Easter eggs used to be left on the doorstep but we were never allowed them.
I desperately wanted to meet my Grandma but I never did, I am still sad about it. Years later, my Cousin mentioned her and was shocked when I told him that I had never met her, he told me that I had really missed something there, that she was absolutely wonderful. I'm sure she was!
Unfortunately by then she had died, she left my Mother an inheritance, I thought that my Mother would not accept it and was shocked when she told me that she had banked the cheque.
Fortunately, I had a brilliant paternal Grandma, who I absolutely adored, more than anyone, I would say.
A few years ago I searched my Family History and felt quite emotional when I found her.