My skin seems to be ridiculously sensitive to laundry residues. I've been avoiding any laundry powder containing perfume for years but I was still getting odd skin problems that I couldn't narrow down to anything else. So I now put a small amount of washing powder in the prewash compartment and do a prewash, then a main wash using just water, 60° for some things (towels, bedding, etc), 40° for others. It seems to have made the difference. Clothes also feel softer, even without fabric conditioner which I only use on acrylics (mainly Minibags's stuff).