Houses in cul-de-sacs are usually fairly modern houses, whether that attracts people, possibly potential buyers also think that cul de sacs will be more friendly as they usually consist of a small cluster of houses looking at each other.
My worry about cul-de-sacs, is their dangers to children. They are usually narrow and curvy with inadequate parking and cars are forever backing to and fro because of the difficulties of turning round, the danger to children running around or playing on bikes is obvious.
We have lived in cul-de-sacs, both just long roads with dead ends, not the arrangement most people think of. I have also lived on a busy road, quiet through road and now something between the two, a short access road parallel to the public serving three houses.
To be honest I have no preference for one location over any other. For me it is the house itself and the broader locality tha tmatters.