I don't know what to say Oakwoodhospital; a very difficult situation.
Not being, or having been in your situation, I'm trying to think what I would do in your position. My instinct, if this were my son would be to suggest that he stop being at her beck and call. If she can't manage without his help, she should have thought about that before telling him to leave.
How are all of these arrangements fitting in with the current restrictions? I don't want to be rude but why on earth is he taking her to London, to her friend's house, for a weekend party?
Would it have perhaps been better if you'd not agreed to have the children so she'd have had to make her own way there, or missed the party altogether?
From your OP it looks very much as if your son, over the years has given so much ground that he's backed himself into an impossible situation.
If she is thinking about going abroad to her family, your son must get some legal advice and secure his legal right to have contact with his children. Once secured, it is extremely unlikely that she would be able to relocate abroad with the children, without his consent.
IMO your son needs to stop dancing to her tune and get some legal advice to secure his own position in the lives of his children.
I hope you can persuade him to do so and to stop giving into her domineering and controlling behaviour.