FINALLY A BREAKTHROUGH FOR HG! The HER Foundation, researchers at UCLA and USC, and 23andMe, Inc. have conducted the first genome-wide analysis of Hyperemesis Gravidarum (HG) and identified 2 genes associated with HG, as published this week in Nature Communications. Contrary to popular belief, the study does not support a role for pregnancy hormones estrogen and hCG. In further work presented at the ICHG last October (bit.ly/ichgfejzo), Dr. Fejzo presented that not only were the genes GDF15 and IGFBP7 linked to HG, but also, their proteins are abnormally high in HG patients. These genes are turned on in the placenta in early pregnancy and code for proteins that regulate appetite.
Dr. Fejzo says “prior research has shown GDF15 is a regulator of physiological body weight and appetite via activation of neurons in the hypothalamus and area postrema (vomiting center) of the brain.” GDF15 and IGFBP7 also play a role in cachexia, a disease with similar symptoms to HG, debilitating fatigue, weight loss and muscle wasting, that causes death in about 20% of cancer patients. These findings may lead to genetic screening to predict which women will have more severe symptoms and need more proactive therapy. This information should put an end to the misconception that HG is “all in your head” and opens new avenues for diagnosis, research, and novel treatments. We are hopeful that this breakthrough will ultimately improve the care mothers receive and the health of mother and child long-term. We thank all our study participants and donors-we could not have done this without you!
UCLA: bit.ly/ucla0318
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