There are so many factors
My personal situation, my mother estranged herself from family for long periods of time. She also tried to alienate me from my father, going as far as to threaten making me homeless.
I didn't learn estrangement from her though, I held on for half a lifetime before she drove me to a nervous breakdown and with the help of my own family and professionals I estranged.
I think there are two main ways to estrange someone, to hurt or punish or to protect yourself. So my estrangement is ultimately different to my mother's as she used it to punish people and I used it to protect.
I don't think the question is really whether estrangement runs in families but whether dysfunction, differences of opinion or abuse runs in families. Many I have seen discuss estrangement involve an abusive "other" whether parent or child.
However, I do not take anything for granted, I continue to try to heal myself and take responsibility for any mistakes or periods of being unwell. I continue to love my children unconditionally which they all make very easy to do.
That is the major difference between my mother and I, I am able to be accountable and she is not and justifies her behaviour or plays victim.
Everything I can do to prevent the cycle continuing will be done and at this point my personal relationships outside of my immediate family have always remained positive.