there is a family history of underactive thyroid in my family so I take a very low dose of thyroxin but always take mine in the morning with water before food
when I fist started on the course it seemed to lift me quite well - but 4 years on I am starting to feel tired by the afternoon so I might need to increase the dose (for longer lasting effect) - on the other hand it could be age 
I can see the logic that taking it at night would ease the morning tiredness - but suspect the 'down' feeling would kick in sooner. may give it a try and would be interested to hear what other GNetters find
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