In New Zealand bees which forage in areas where there is a high density of Manuka blossom produce a honey with a characteristic scent and different degrees of antiseptic qualities. Think of Heather Honey for example (though it has no antiseptic qualities). It is regular honey but with a slightly different flavour. Manuka honey is not used differently, you just spread it on your toast or take a spoonful for your sore throat.
The manuka honey with a high level of antiseptic properties is prohibitively expensive as little of it is produced. The type you buy here which is not too expensive is not going to be effective. Much of it is fake. Some of it is tested and the "Manuka factor" certified. Certification is often faked.
If you are receptive to the placebo effect and have loads of money to waste by all means go for it. Buy the highest rating you can find and hope it is genuine.
The only scientific evidence showing a benefit from Manuka honey is on wound dressings using the highest quality strain. The rest is marketing and hype.
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