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Side effects of medication

(36 Posts)
RosieandherMaw Fri 21-Nov-25 12:13:39

Not the most inspiring title but are you, like me, finding more and more that something you take for one problem, then goes and causes another? How to keep the balance?
For instance, I swear by magnesium tablets to keep leg cramps at bay at night. These can be excruciating and totally destroy a nights rest. BUT after two weeks of the “dire rear” for no apparent reason I decided to look up magnesium supplements, and yes, they have a laxative effect directing more water/liquid into the gut.
Then there’s ibuprofen for the twinges of the old Arthur-itis.
NSAIDs like ibuprofen, naproxen etc while effective go for my stomach, causing reflux and often considerable pain!
So it’s a question of balance and compromise, how have you dealt with this?

RosieandherMaw Sat 22-Nov-25 22:30:04

butterandjam

RosieandherMaw

My experience is just that - personal experience plus common sense!
Which outweighs the other though?

Common sense suggests, read the leaflet in the box with special attention to the sections on "contra-indications" and
"interactions with other treatments."

NSAIDs like ibuprofen, naproxen etc while effective go for my stomach

www.nhs.uk/medicines/nsaids/

"Possible side effects of NSAIDs include:

indigestion – including stomach aches, feeling sick and diarrhoea

stomach ulcers – these can cause internal bleeding and anaemia;

Some NSAIDs can react unpredictably with other medicines.
This can affect how well either medicine works and increase the risk of side effects. "

I’m not talking contraindications but the acceptability or otherwise of side effects.
Sorry if this wasn’t clear

RedRidingHood Sat 22-Nov-25 22:01:16

Iam64

I take several prescription drugs as I have several auto immune conditions and AF
I decided in my forties when RA was limiting my work and personal life to take the meds despite fear of serious side effects.
I’m 76 and still creaking. I take magnesium for the same reason as rosiesmaw and occasionally have a break for the reasons identified 🌞

Same here. Rheumatoid arthritis, arrhythmia, asthma etc.
I loathe having to take so many drugs but without them I would be in acute pain and unable to move.
Every drug has it's own side effects. My RA was well controlled for 10 years by one drug but it stopped working as is common with autoimmune conditions. I'm now struggling with awful nausea from a new drug which has in every other respect given me a new lease of life.

It's very easy to say you won't take drugs when you're basically healthy.

Floradora9 Sat 22-Nov-25 21:46:36

My GP looked at the many pills I have been prescribed and wondered out loud what would happen if I stopped taking them . The answer was " You might die of course " .

SusieB50 Sat 22-Nov-25 15:08:18

I have high blood pressure that does require medication. I have been taking several for years , and gradually GP has been increasing the dosage of one diltiazem . I have had a terrible cough for about two years . It was put down to reflux and a hiatus hernia- medication given for that !It started when the GP increased it again and to a daily dose instead of split to twice a day. I read the leaflets of all my meds , none stated a cough as a side effect. But I continued to research and yes diltiazem can cause a cough in high doses as it relaxes the stomach sphincter! I discussed with GP who was very sceptical but agreed to reduce diltiazem and increase another one. Hurray cough is much diminished, no Gaviscon needed and I’m much relieved.

Parsley3 Sat 22-Nov-25 13:01:06

It may have already been mentioned but I use a magnesium spray for leg cramps. It it works for me and seems to avoid the dreaded side affects.

glammagran Sat 22-Nov-25 12:42:40

I started taking magnesium capsules about 9 months ago. I too took them for leg cramps but also for my high, racing heart rate. They have worked remarkably well but haven’t helped my terrible sleep. I put up with the looser tummy but it doesn’t happen every day.

I try to avoid ibuprofen, though it doesn’t cause reflux with me and find paracetamol adequate for arthritis pain most of the time. I found I was very intolerant of drugs to lower my heart rate and also to naproxen for arthritis. We are all very different.

butterandjam Sat 22-Nov-25 12:26:08

RosieandherMaw

My experience is just that - personal experience plus common sense!
Which outweighs the other though?

Common sense suggests, read the leaflet in the box with special attention to the sections on "contra-indications" and
"interactions with other treatments."

NSAIDs like ibuprofen, naproxen etc while effective go for my stomach

www.nhs.uk/medicines/nsaids/

"Possible side effects of NSAIDs include:

indigestion – including stomach aches, feeling sick and diarrhoea

stomach ulcers – these can cause internal bleeding and anaemia;

Some NSAIDs can react unpredictably with other medicines.
This can affect how well either medicine works and increase the risk of side effects. "

IWasFirstClarinet Sat 22-Nov-25 12:25:39

I find that leg cramps tend not to occur if I do calf stretches for about 20 seconds each leg, just before I get into bed. The internet has lots of info on such stretches. They cost nothing and take little time.so always worth a try.

Allira Sat 22-Nov-25 12:19:22

Better loose stools than constipation!

fancyflowers Sat 22-Nov-25 12:18:22

I take magnesium for restless legs which are caused by my poor kidney function. I wasn't aware until I read this thread that they caused loose stools, which I get in the mornings. I would prefer the loose stools to the restless legs though, so I'll keep on taking them.

CariadAgain Sat 22-Nov-25 11:39:54

paddyann54

After months of a cough that kept me awake all night,every night and a horrible scratchy throat I eventually found the cause in my Ramipril. leafletI,ve been on it for decades ,my blood pressure rarely hit the 120/60 the GP said was normal .So Itook myself off it and after two weeks I called the GP and told him what I,d done,the reason I’d done it and the result.

He wasn,t happy that I had taken action without consulting him but as the side effects had lessened considerably he suggested I give it another month and call him
It’s now seven weeks and I can’t sleep through the night with no cough….and my blood pressure is within the range he wanted in fact sometimes it’s under 120/60 .
My GP appointment today however was over 200/100 ." White coat syndrome so I have to fill the monitor list fora week and go back Despite me giving him two weeks of readings that were all excellent .

That is a huge difference for "white coat syndrome" and I'm someone whose blood pressure increases a lot for that - and not just the 5 points I think they allow for that.

Errrrm.....wondering if you "have to....go back" really or is that just what the doctor said? I'm very cynical by now about whose best interest a doctor is speaking in. The mere thought of the current "You're only allowed to speak about one problem during your appointment" diktat is so wrong - given that it's frequent to have more than ailment at a time and that they're often connected.

Me I'm off to see an acupuncturist soon (who has alternatives for the needles I won't let any medic use if I can help it) and it makes so much more sense to me to tell a health practitioner all the bits that are wrong - because even I can see some of them are connected. I'm just going to write out the list of "everything wrong" and put it in order of priority as to what is affecting my life most at the top.

A little alarming to find out that I'm the same one out of the 5 elements that govern temperament as Margaret Thatcher LOL. But I can handle that better than side effects from drugs.

Jaxjacky Sat 22-Nov-25 11:27:42

I’m not allowed NSAIDS, risk of stomach bleed, paracetamol only, MrJ uses a magnesium spray for his occasional night cramps.

Greenfinch Sat 22-Nov-25 11:05:18

Thanks argymargy. I hope those people are well monitored and their families are told. My friend never had this explained to her so consequently she refused to take it having read about the possible consequences.

paddyann54 Sat 22-Nov-25 11:02:43

Aveline the GP told me he thought it was allergies so told me to take antihistamines….then it was caused by the. central heating going on,could be dust mites in your bed Mrs paddy …change of temperature during the night ? Might be athsma?
I got so fed up with the wrong diagnosis that I just thought about it
What did I do before bed that might cause it overnight and the ramipril was the only thing that I took every night ..so I checked the leaflet and there it was top of the list of side effects .
I wouldn’t tell anyone else to just come off a prescribed drug but I felt I needed to see results before I went back .
I am delighted that I and my long suffering OH can now sleep all night .
So here I am T almost 72 with only my HRT I,v e ditched the things he prescribed for things I don’t have .

argymargy Sat 22-Nov-25 07:51:32

Greenfinch

A friend with psychotic depression was prescribed a drug whose side effects mentioned suicidal thoughts. You couldn’t make it up !

It’s not made up. It is an understood outcome of treating severe depression that some people may be sufficiently drawn out of their deeply depressive state to be able to contemplate suicide and possibly act on these thoughts. It’s shocking but it can happen.

Aveline Sat 22-Nov-25 06:55:32

paddyann I'd read about the dreaded 'Ramipril' cough on GN and told DH about it. He was certainly suffering as you were. The GP changed the prescription and lo and behold that irritating dry cough disappeared.

Allira Fri 21-Nov-25 22:37:07

I take magnesium tablets but they don't give me the dreaded dire rear, perhaps they're not high strength.
In fact, because I'm taking iron tablets which can cause a different type of *dire rear^, they do help alleviate that!
Remember our mothers dosed us with Milk of Magnesia occasionally, if we had a problem with going to the loo?

As for anti-inflammatories, the GP bannd me from taking
them. They are not good for the kidneys, apparently.

Calcium tablets to help prevent bone loss? Can leave deposits in heart, kidneys, blood. Vitamin D ditto.

Medication prescribed to teenagers for acne? Read the contra-indications.

I take Bioglan magnesium, RosieandherMaw, it seems to alleviate cramps without causing the other problems.

Greenfinch Fri 21-Nov-25 21:54:57

A friend with psychotic depression was prescribed a drug whose side effects mentioned suicidal thoughts. You couldn’t make it up !

Deedaa Fri 21-Nov-25 21:48:29

My daughter was given medication for backache. Being a scientist the first thing she did was read the leaflet. The "more serious" side effects were vomiting blood and death. She queried this with a friend who is a pharmacist. He said "This is for rheumatoid arthritis, which you haven't got! Do not touch it"

Babs03 Fri 21-Nov-25 21:34:55

paddyann54

After months of a cough that kept me awake all night,every night and a horrible scratchy throat I eventually found the cause in my Ramipril. leafletI,ve been on it for decades ,my blood pressure rarely hit the 120/60 the GP said was normal .So Itook myself off it and after two weeks I called the GP and told him what I,d done,the reason I’d done it and the result.

He wasn,t happy that I had taken action without consulting him but as the side effects had lessened considerably he suggested I give it another month and call him
It’s now seven weeks and I can’t sleep through the night with no cough….and my blood pressure is within the range he wanted in fact sometimes it’s under 120/60 .
My GP appointment today however was over 200/100 ." White coat syndrome so I have to fill the monitor list fora week and go back Despite me giving him two weeks of readings that were all excellent .

Well, well, for years my husband was on Ramipril and he was up in the night coughing with an itchy throat. They kept saying was his sinuses, and he does have trouble with his sinuses, but due to it being discovered that my husband has atrial fibrillation he now takes 5mg bisprolol - probs wrong spelling - which are beta blockers and so brings down his BP, therefore he hasn’t taken Ramipril for many months and surprise, surprise the irritating cough has not occurred for many months.

keepingquiet Fri 21-Nov-25 21:33:04

Mollygo

Some years ago I was given a pain relief medication with a listed side effect of if you stop taking this you could die!
I refused to take it until the doc explained that I would only be taking it in the short term and the dosage was small. When I didn’t need it any more I had a few nervous weeks.

At the age of 40 I was told I had to take medication for the rest of my life.

I stopped taking it altogether almost ten years ago and I am very much still here...

paddyann54 Fri 21-Nov-25 21:28:33

Can sleep through the night

paddyann54 Fri 21-Nov-25 21:27:46

After months of a cough that kept me awake all night,every night and a horrible scratchy throat I eventually found the cause in my Ramipril. leafletI,ve been on it for decades ,my blood pressure rarely hit the 120/60 the GP said was normal .So Itook myself off it and after two weeks I called the GP and told him what I,d done,the reason I’d done it and the result.

He wasn,t happy that I had taken action without consulting him but as the side effects had lessened considerably he suggested I give it another month and call him
It’s now seven weeks and I can’t sleep through the night with no cough….and my blood pressure is within the range he wanted in fact sometimes it’s under 120/60 .
My GP appointment today however was over 200/100 ." White coat syndrome so I have to fill the monitor list fora week and go back Despite me giving him two weeks of readings that were all excellent .

RosieandherMaw Fri 21-Nov-25 21:25:34

That’s helpful, thank you.
I was debating which I could cope more easily- loose stools or excruciating cramps a!
Holland and Barrett here I come!

Angelnan Fri 21-Nov-25 17:07:55

There are several types of magnesium supplements. Magnesium citrate causes diarrhoea and is used as a bowel prep before gut surgery under a different name . Magnesium glycinate doesn’t have the same effect and aids sleep, cramps etc. The other issue is dose . Many supplements don't have sufficient active component to be effective. Research and medical advice always recommend. No medication is without side effects and it needs to be balanced to ensure you are taking the best route.