Can Ovestin cream cause depression?

Actually, Mandrake, I think you may have a point. I tried Ovestin for the first time before Christmas and it made me feel pre menstrual and extremely grumpy. Estriol did not make me feel like that so I am going back to doctor to see if I can go back to original cream.

That's a good point. If I am more comfortable I'll feel happier. I think it's helping. I've always been very sensitive to hormones though and could never use hormonal birth control. Maybe it's just the holiday funk. I went and did something and felt a lot better.

Well I’ve used it for a year now and would say the opposite. No UTIs and much more comfortable in the lower area.