There is little point in talking about regime change at present, however desirable we all might find it.
Iran’s regime is at present totally embedded, and although it is supported probably only by between 20-30% of the population, it holds all the cards in as much it entirely controls the military and the economy as well of the social infrastructure etc, so those Iranians who long for change - it must not be forgotten that change does not mean to something more amenable to the west and certainly not Israel.
I think that Netanyahu understands this and so his goal is simply to degrade Irans military power so that it is no longer a threat to Israel. Netanyahu has no wish to “save”the Iranians from their oppressors.
Trump doesn’t know what he wants, except of course the chance to further enrich the Trump dynasty.