For me, the biggest challenge is recognising, and understanding, the long-term side-effects of medications.
If, as we age, more and more drugs are added to the schedule, the side-effects can be profound.
GPs etc cannot be expected to have a complete knowledge of all the drugs they prescribe, so I think it has to be up to the patient to do the research. However, this can be exhausting and time-consuming.
The reason why I think this is important is because symptoms which sometimes send patients to their GP because they think they might be developing a 'new' problem, might well be a lot more to do with the possible long-term side-effects of the drugs they are taking.
Obviously, some side-effects of specific drugs are well-known and GPs might recognise them... but - the long-term effects, not so much.
In my own case, one specific drug has caused immense problems - but it's only because I've done a huge amount of research that I've been able to understand them. And, more importantly, take action to counteract such effects. I should add that I've done this with the approval of the pharmacist at my local surgery who has been willing to spend some time discussing the issues.
However, how many patients are suffering from side-effect, long-term, and don't recognise that fact?