What are these orange stains that have appeared on my hands overnight?

I don’t think it matters if people experienced this phenomenon before the vaccine rollout. If you had this 10 years ago it may very well be an adverse reaction to a vaccine or close proximity to someone who was vaccinated.

pubmed.ncbi.nlm.nih.gov/34310755/

??? Is this the answer to our question?

www.ncbi.nlm.nih.gov/pmc/articles/PMC8447431/

I’ve researched for answers and my suspicion has been the vaccines. www.ncbi.nlm.nih.gov/pmc/articles/PMC8447431/

We describe a reaction that occurred in three cases after the BNT162b2 mRNA COVID‐19 vaccine (Comirnaty®; BioNTech, Mainz, Germany and Pfizer, New York City, NY, USA). All cases were female, two of them aged 50 and one 51 years. All subjects had experienced a similar reaction after vaccination; part of their skin turned a brownish, rust‐like colour. The respective locations of these reactions were (i) the left palmar area and right arm (Fig. 1), (ii) the dorsal surface of the left hand and (iii) the right palm and fingers (Fig. 2).

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Figure 1
Reaction in left palm.
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Figure 2
Reaction in right palm.
Two of these reactions occurred after the first vaccination and one after the booster. In the case of the booster, the reaction was observed approximately one and a half hours after the vaccination. In those subjects receiving only one vaccination, the reactions appeared the following night and after 5 days, respectively. All subjects are healthcare workers working with elderly people, and thus among the first to be vaccinated in Finland. All three had been previously vaccinated according to the Finnish national vaccination programme. They had also received the annual influenza vaccine required for healthcare workers. Two of these individuals had a known IgE‐mediated allergy to pollen, and one of them also had a contact allergy to nickel. Those with a history of IgE allergy had taken paracetamol (acetaminophen) prior to vaccination, and the other one had also taken cetirizine an hour before. All the reactions subsided in 24 h, due to which no biopsy specimen could, for practical reasons, be taken. All three had pain at the vaccination site for two days as another adverse event; two out of three also experienced some flu‐like symptoms the following day.

We have no idea of the possible mechanism for the phenomena, but, interestingly, all patients were of the same age. Pollen allergy is very common in Finland, and the relevance of the atopic diathesis remains unclear. A delayed reaction to another mRNA‐based vaccine (mRNA‐1273) has been reported, 1 but the reactions described are of a classic inflammatory nature. A similar reaction has also been reported for the BNT162b2 vaccine. 2 , 3 In a registry‐based study with 414 reported cases with cutaneous reaction, altogether four cases of petechiae were reported 4 but not described in more detail.

The reaction we now describe would suggest a haemosiderin pigmentation, but vanishes too rapidly to be explained as such. We suspect that this reaction is a local capillary leakage due to the vaccination and some kind of immunologic reaction located in the dermis/epidermis junction.

I think it is from the food! It seems whatever we ate had been circulating in our bloodstream and the reason we awaken to this weird phenomenon. Have you been vaccinated?

Orange45

www.ncbi.nlm.nih.gov/pmc/articles/PMC8447431/

I’ve researched for answers and my suspicion has been the vaccines. www.ncbi.nlm.nih.gov/pmc/articles/PMC8447431/

I'm sure you've solved it Orange45. Well done!

Very interesting Orange but I don’t think it’s the vaccines per se. I first experienced the rust marks in January 2020 before Covid had arrived yet alone a vaccine. Prior to that I had a flu vaccine in 2005. What I now suspect is that it’s some kind of allergic reaction. With the case studies you outline it was the Covid vaccine which for some was a serious reaction with rust marks on the arms as well. For me it was eating red Romano peppers. I do suffer from the odd allergy as well.

So how many on here suffered from allergies? Allergies could definitely be the link.

So interesting Orange that the medics couldn’t give a definitive cause or how it manifests itself. Maybe they will look a little closer now.

I first experienced the rust marks in January 2020 before Covid had arrived yet alone a vaccine
25Avalon Many of us believe that Covid arrived here at least in December 2019, or if it was not, it caused very similar symptoms which lasted for weeks, including months of marks on my hands.
The marks I had on my hands after having the virus at that time and later on diagnosed Covid were like very tiny purple/black bruises. The area got hot and painful then it seemed as if a capillary burst and a bruise appeared. It wasn't yellow.

Some of the marks in the photos look like stains from lily pollen which I had last week but that would be too obvious!

True Callistemon but the point I was making was that there was no vaccine when I first experienced these rust marks so mine weren’t the result of vaccine or having Covid. The common correlator seems to be an allergic reaction.

I agree the marks look like Lily pollen stains but after scrubbing and scrubbing you come to realise it is internal.

Sorry about your horrid experiences with Covid.

I hadn't realised the tiny bruises could be Covid-related until I read something on here 25Avalon

They're not yellow though.

A bit different than Callistemon but so much about Covid that we still don’t know. It could cause the rust marks but I don’t think that’s so in my case. So many people though on this thread suddenly waking up with it in the past 3 years since I started this thread. Makes you wonder, is it a new phenomenon? Anyone experience it prior to 2019?

Well done Orange45 I have never experienced this but have found it intriguing every time it pops up on the forum.

So I joined to comment! I have had this since I was probably 10. I did ask My mom when I was younger and she said it's callous. Well I googled it now and it's not. I'm also 28 now female not pregnant

https://www.gransnet.com/uploads/talk/202306/medium-801678-1000002401.jpg https://www.gransnet.com/uploads/talk/202306/medium-178813-1000002400.jpg

See pic

I think it's just a food thing. Carotene is in much more than we think!!
Either that, or you've all been touched by aliens 👽
I like the 👽 theory best! 😆

vm.tiktok.com/ZM2AERMnc/

Capillary leak syndrome (CLS) emerged as new adverse event after immunization (AEFI) associated to COVID-19 vaccination. CLS is a rare condition characterized by increased capillary permeability, resulting in hypoalbuminemia, hypotension, and edema mainly in the upper and lower limbs. Our pharmacovigilance study aims to evaluate the CLS onset following receipt of COVID-19 mRNA vaccines (mRNA-1273 and BNT162b2) compared to viral vector vaccines (Ad26.COV2-S and ChAdOx1-SARS-COV-2). We carried a cross-sectional study using all Individual Case Safety Reports (ICSRs) reporting a COVID-19 vaccine as suspected drug and CLS as AEFI, which were collected in the pharmacovigilance database EudraVigilance from January 1st, 2021, to January 14th, 2022. We applied the Reporting Odds Ratio (ROR) 95% CI for the disproportionality analysis. During our study period, CLS was described as AEFI in 84 out of 1,357,962 ICRs reporting a vaccine COVID-19 as suspected drug and collected in the EV database. Overall, the ICSR reported by CLS were mainly related to the viral vector COVID-19(ChAdOx1-SARS-COV-2 = 36; Ad26.COV2-S = 9). The mRNA COVID-19 vaccines were reported in 39 ICSRs (BNT162b2 =33; mRNA-1273 =6). Majority of ICSRs were reported by healthcare professionals (71.4%). Majority of the patients were adult (58.3%) and the female gender accounted in more than 65% of ICSRs referred both to classes vaccines. In particular, women were more represented in ICSRs referred to mRNA-1273 (83.3%) and to ChAdOx1-SARS-COV-2 (72.2%). The CLS outcome was more frequently favorable in mRNA ICSRs (33,3%) than the viral vector ones (13.3%). Among the ICSRs reporting CLS with unfavorable outcome, we found also 9 fatal cases (BNT162b2 = 1; ChAdOx1-SARS-COV-2 = 4; Ad26.COV2-S = 4). From disproportionality analysis emerged a lower CLS reporting probability after vaccination with mRNA vaccines compared to viral vector-based ones (ROR 0.5, 95% CI 0.3–0.7; p <0.001).Our findings, even if subject to the limitations of spontaneous reporting systems, suggest a small but statistically significant safety concern for CLS following receipt of COVID-19 viral vector vaccines, in particular with Ad26.COV2-S. Cytokine-release following T-cell activation could be involved in CLS occurrence, but a precise mechanism has been not yet identified. COVID-19 vaccines remain attentive as possible triggers of CLS.

www.ncbi.nlm.nih.gov/pmc/articles/PMC9513245/

www.patientcareonline.com/view/discoloration-palm-wont-wash

No such thing as aliens

https://www.gransnet.com/uploads/talk/202306/medium-740153-5d89c38f-56c0-4a5a-b131-fe3392558b2e.jpeg https://www.gransnet.com/uploads/talk/202306/medium-723069-f0ab1617-3eb4-4eaf-9676-6113a2635117.jpeg https://www.gransnet.com/uploads/talk/202306/medium-974729-9a8404d7-7b7e-4f62-b7d6-30550650aec6.jpeg

hello, i’m definitely not a gran BUT this is the only place talking about this issue. i woke up at 3 am to pee and saw this on my hands and feet. i’m so confused. i can’t scrub it off.

Thank god I have found somewhere that has at least a couple of people who are experiencing this as well.

I'm a 32 year old male, from the UK and this morning I woke up to these Iodine looking marks on my right hand, they were pretty small but I noticed then in my nail beds, across my lower palm and my thumb. Over the day they have faded and there has beeb no pain with them, I had a Dr app and asked them about it and they didn't say much.

I suffer from a disease called red ear syndrome, I also have back issues.

Food wise I had a curry with rice, naan & poppadoms and then generally the food during the day, the only thing changing is moving to a dark chocolate and nut breakfast bar, I also drank 2litres of capri sun juice.

If it continued and got worse I'd likely go back to my doctors, but if anyone finds anything let us know!

CalTrey
Check the ingredients of CapriSun. There might be carotene in it.

Why do people think Covid wasn't here before 2020?
It's called Covid-19 for a reason!!
My OH & one of my GC had it before we were told what it was - I'd never before seen staff in Boots so worked up than when we went in for advice, they gathered in a little group and looked so worried that we knew it wasn't a run-of-the-mill flu!!

Hope everyone here is doing good and healthy. Cheers!

I woke up with the same thing and i hadnt touched anything that could have cost those stains. Googled and found this. He also had a fever and abdominal though.

journals.lww.com/ders/fulltext/2021/39030/yellow_vesicular_palmar_eruption_in_a_young_man.19.aspx