Our DD & SIL went through 3 rounds of IVF. DD isn't a great communicator at the best of times, they lived a long drive from us so most of the info I had about the process came from a young friend of mine who'd been through it herself,or from SIL. It was a harrowing time for both of them, not only mentally but physically & the desperate disappointment after each failed attempt was so painful for them & also for us. 3 times was enough and they gave up and, as we thought, settled into a childless marriage...only they didn't, they split up and I'm sure the failed IVF was a root cause. I'm amazed Twiglet's son & DIL have managed 5 rounds, they must be at their wits' end & I can't imagine the toll on DIL's body. It's hard to stand by & not interfere but I'm sure you must be feeling, as we did, that enough is enough & if it hasn't happened by now, it's almost certainly not going to. I too wanted to wave that magic wand. I feel very sorry for you, it's not a good place to be in.