I think it depends on the structure of the family and who is in the single rooms. It also depends on the relative financial circumstances of those involved, and the purpose of the stay.
If the single people are young, or much older than the couples, and have less money, I would split the bill in a way that made it cheaper for them. If everyone is the same generation and of similar means, then everyone should sort out their own bill.
Also, if the trip is optional and for fun, so people can choose not to go if they will be stretched by doing so, that’s different from something like a wedding or funeral that is harder to get out of. In the latter circumstances it would be a kind gesture to make the bills equal per person, rather than half price for members of couples.
I don’t think it is a ‘one size fits all’ situation where families are concerned.