Looking after grandchildren should be a pleasure and not a chore. When it starts becoming a chore, you should give it up. You had 2 children of your own, so there must have been some maternal feelings there.
I shared childcare (with in laws) of my 2 older grandchildren (teenagers now) from the time , my daughter went back to work, after maternity leave. The only time I was really stressed was when my little granddaughter (3years old at that time) had a tummy bug with projectile vomiting and cried continuously for her mum. So, I had to ring my daughter, who promptly came back from work.
The fact remains that the older we are, the more tired we get and less able to do more than a couple of hours of childcare. That's where I'm at now. My sons have very young children and I have made it very clear, and they understand, that childcare will be limited to a couple of hours of babysitting, when needed. That's it. I'm older now, than when my daughter's children were born.
Talk to your son and daughter and lay your cards on the table.
Good luck !
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