My feeling is there is a bit too much scare mongering about a lot of prescription medication. I spent 6 months in significant pain, and with decreasing mobility as I pondered whether to take the methotrexate my rheumatologist wanted me to take. I was genuinely scared silly by the list of possible side effects. My GP was brilliant, and when I asked what he'd do in my place, he said 'take the drugs', yes there are risks, but with inflammatory arthritis, the risks are the same as with the drug, but worse. So, I took the drug, at a very low level and within 4 weeks could walk my dogs 2 miles. I could also get out of bed, and walk downstairs, something I'd found so difficult for months. I was 46, and here I am, still on mtx, no side effects at all. I've had another treatment added after a flare up 4 years ago had me struggling again.
So far as ante depressants go, I have in the past taken fluoxetine (prozac) at a time when my arthritis was stopping me doing much, frankly. It was a wonder - and helped me through until the new disease modifiers kicked in. I have also worked with many people who suffer anxiety/depression. I've seen the improvements that come as mental health improves