I imagine if you investigate all drugs, prescription and otherwise, there won't be any without some side effects. Not everyone experiences side effects and you have to weigh up what is the best option, suffering the medical condition, or medication side effects. I have been prescribed Omeprazole for ibuprofen induced gastritis for years, but only take infrequently. Anti inflammatory drugs such as ibuprofen also have an increased heart risk, but can be a godsend for arthritis sufferers. I don't know whether it's coincidence, but since reducing carbohydrates in diet I need omeprazole much much less, (and I do not use ibuprofen).