Many years ago I had a rash on my face which was red, shiny, hot and incredibly itchy, apparently caused by a streptococcal infection in my nasal passages. I couldn't take antibiotics because I was pregnant and the itching drove me insane. I had an appointment with a dermatologist and he prescribed some cream which relieved it but I couldn't take the antibiotics until I had stopped feeding the baby.
I remember the itching being indescribably awful.
I had to have a long, slow course of an antibiotic, it may have been tetracycline.