I was prescribed Omeprazole years ago, probably when it first became available. I'd suffered badly from acid reflux and heartburn for a long time and had been on ranitidine which was becoming less effective. It was a godsend, it's a brilliant drug. However, I was eventually reduced to the maintenance dose of 20mg and told I would be on it for life. Therefore, when it came up for review every year, my GP merely okayed it without ever seeing me.
Last year, I began to have different digestive problems and losing a lot of weight without trying. When I eventually saw the GP at my new practice, I was fast-tracked through various procedures to rule out cancer. One of these was an upper endoscopy which meant I had to stop the Omeprazole a fortnight beforehand. I was prescribed Gaviscon Advance to take 4 times daily instead. This caused me no problems at all, no symptoms of heartburn or reflux. I discussed not resuming the Omeprazole with the endoscopist and he was amenable to my not doing so and to continue with the Gaviscon. If symptoms reappeared I could possibly be prescribed a different -azole.
I'm still not taking Omeprazole a year on and gradually tapered off the Gaviscon. No acid reflux! My appetite and enjoyment of food has returned though I do have to watch what I eat, nothing fatty or acidic. Omeprazole suppresses acid production in the stomach but as you get older, your stomach often naturally produces less acid. My theory is that the two things together were producing my digestive symptoms...full after a few mouthfuls, bloating, meat meals sitting around in the stomach for ages, presumably because the necessary acid wasn't there to digest it. I also think the weight loss was helpful, no longer the big belly pressing on the valve at the top of the stomach and causing the food to reflux back up.
Incidentally, the weight loss was purely due to the stress of buying and selling a house and my interior seems to be in good working order.
However, we are all different. Definitely do not come off by yourself but only after discussing it with your GP.