Have your family ever suggested that you move nearer to them?
Would they have the time or be willing to help you as you grow older.
Only you know!
From what you have said, you love your house and it would upset you to leave it. You also have a circle of long time friends and socialise regularly.
Those are two big pluses to stay put.
The work next door, will probably be quite noisy for a while but only in the daytime and perhaps you could visit friends more during the days of most disruption.
Also, I wouldn't be bothered about the neighbours, as long as they are not being deliberately nasty to you. Quite rightly you have a Party Wall Surveyor, to look out for your interests, so would anyone with a neighbour having this work carried out.
I don't bother about being too friendly with neighbours, ever since I had one who became very intrusive, a pleasant hello is all that is needed.
You might find that your close friends would be more supportive as you get older than family would be.