Hi there, just read your thread. The same thing that happened to me in November 21, aged 47. After applying my second patch (Evorel 50), 3 days in I get the wired agitation, like I was on drugs, like you. I rip the patch off and then few hours later, whilst walking around local supermarket, everywhere goes black, feeling of doom, like I was about to die. Horrible. I told my gp, who said I was maybe sensitive to the estrogen or too high a dose and id had a withdrawal reaction. The thing is, I havent felt stable since. 2022 was very up and down, ad's that I've been on since 2018 not so effective and various physical stuff going on.
So now, having just had Covid at Christmas for the first time, my period is very very absent but I feel like I'm into a prolonged and heightened pmt!!!
Re HRT, may speak to gp at some point or a local Menopause, but that would cost quite a bit.