I hadn't realised there were quite so many.
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Gareth Johnson, government whip
An MP in charge of getting colleagues to vote for the PM's Brexit deal quit himself to vote against it on the eve of the poll.
Gareth Johnson stood down from the whips' office calling the agreement "detrimental to the nation's interests".
30 November 2018Sam Gyimah, universities and science minister
The universities minister resigned in protest over Mrs May's Brexit deal while she was in Argentina at the G20 summit.
Sam Gyimah, who campaigned for Remain but represents a Leave constituency, is campaigning for another referendum.
15 November 2018 10:22amSuella Braverman, junior Brexit secretary
A wave of ministerial resignations after a draft deal was reached with Brussels ended with the loss of Brexit minister Suella Braverman.
The Fareham MP quit saying the Northern Ireland backstop "is not Brexit" and it threatens to "break up our precious union", which she said "could have been avoided".
15 November 2018, 10amEsther McVey, work and pensions secretary
Work and Pensions Secretary Esther McVey became the second cabinet minister to quit that day, calling the draft Brexit agreement "a risk I cannot be party to".
One of the most vocal opponents of the deal, Ms McVey reportedly had a massive "bust-up" with Mrs May during the five-hour meeting in which the cabinet agreed to the draft text.
15 November 2018, 8:50amDominic Raab, Brexit secretary
Dominic Raab became the first secretary of state to resign after the draft deal was reached with Brussels, saying he could not in "good conscience" support it.
"I cannot reconcile the terms of the proposed deal with the promises we made to the country in our manifesto at the last election," the outgoing Brexit secretary wrote in a letter to Mrs May.
15 November 2018, 7:20amShailesh Vara, Northern Ireland minister
Earlier that morning, the first minister left the government over the draft deal.
Shailesh Vara quit the Northern Ireland office saying the agreement "left the UK in a halfway house with no time limit on when we will finally be a sovereign nation".
10 November 2018Jo Johnson, transport minister
Proving that Brexit can divide families just as much as the rest of politics, Jo Johnson, brother of Brexit campaigner Boris Johnson, quit as a transport minister.
He warned the UK was "barrelling towards an incoherent" divorce and called for another referendum on the final terms of Brexit.
16 July 2018Guto Bebb, defence minister
Guto Bebb resigned as a defence minister in a surprise move ahead of a vote in the House of Commons.
He quit the government to vote against an amendment tabled by Leave-backer Jacob Rees-Mogg, complaining that "the Brexit that is being delivered today could not be further from what was promised".
9 July 2018Boris Johnson, foreign secretary
One of the biggest figures of the Brexit campaign, Boris Johnson quit as foreign secretary over the Chequers proposal.
A closely watched figure in Westminster because of rumours of a leadership challenge, the former mayor of London said the Brexit dream was "dying"under Mrs May.
8 July 2018Steve Baker, Brexit minister
Brexit minister Steve Baker quit just after the adoption of the Chequers proposals - Mrs May's plan for a future relationship with the EU.
"I cannot support this policy with the sincerity and resolve which will be necessary," he wrote.
8 JulyDavid Davis, Brexit secretary
Earlier in the day, the minister who led the UK's Brexit strategy from the beginning stood down over Chequers.
David Davis said he feared the UK's "negotiating approach" would only result in "further demands for concessions" from the EU.
Other resignations
More senior Conservatives have quit as aides to ministers over Brexit.
Those who resigned as parliamentary private secretaries to speak out about the progress of Britain leaving the EU are: Anne-Marie Trevelyan, Ranil Jayawardena, Will Quince, Scott Mann, Robert Courts, Andrea Jenkyns, Chris Green and Conor Burns.
Several vice-chairs of the Conservative party have also stood down over Brexit, including Ben Bradley, Maria Caulfield and Rehman Chishti.