Without knowing anything other than what you have told us, might I suggest that you think you look awful because you feel awful?
Being permanently exhausted will inevitably show in your face,and your illness is probably affecting your hair too but most of all your self-confidence. Hopefully you are still the same lovely petson you have always been inside so how about treating yourself to things like reflexology (heaven) neck and shoulder massages to ease tension, aromatherapy to lift your spirits a little and a good cut (and colour if you want) for your hair. Beauty counters are not always the best places for unbiased advice, but a good tinted moisturiser (e.g.Bobbi Brown) or Liz Earle skin tint over their lovely neroli moisturiser may make you FEEL better. Different colours of clothes may help, try scarves in colours which "lift" your face - you will know best which outfits make you feel good so WEAR THEM!
Your friends and family will not be nearly as critical as you are of yourself so work on the inside if you possibly can.
If that fails, do what I do, leave the glasses off when looking in a mirror!! 
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A Light Hearted Look at Nicknames



