Big family accommodation in Rome...

Sorry, NotSpaghetti, I usually check carefully before posting and make sure I read all the other responses too but I was ill in bed yesterday (now tested positive for Covid - yuk) and not at my best. I see now that only one small Landmark Trust property (Keats as you said) is in the centre. Sant' Antonia is not far away and looks amazing but sleeps 12 and I see you need bigger. I remember reading about some nuns who have a property right in the centre of Rome where people can holiday and if I find details and they seem suitable I will pass them on.
I hope you find what you are looking for and have great time.

Thank you Nacky - get well soon.
I read there's quite a lot of Covid about at the moment- two new major strains.

I'm not rushing to book anything yet and expect we will have to split into (say) 3 places unless I want a new mortgage! 🤣

I really loved the Villa Borghese suggested by Norah and will definitely keep that in the mix if I go just with my husband!
I saw an equally lovely place quite near Florence that I have on my "just the two of us" list.

Thank you - and I hope you avoid Covid (and the other nasties around too).
Some lovely suggestions here and great that you are finding options for the two of you as well as for the big family holiday. I think so much of the pleasure is in the holiday planning and thank you for opening up the sharing of ideas in this thread.
My only experience of recent multi generational holidays is a short Fred Olsen cruise a few years ago. Not as big a group as yours but it was great fun for all of us - ages 13-80 - and very easy.

I confess it was 18 months between booking the holiday in Wales and actually going.

I wasn't sure that a traditional beach holiday would work as well as it did but they family immediately tried to book the same cottages for the same week the next year (2026) .... two of the four were already booked by the time we got home - so we will go back in 2027 instead.

Already booked!