Two of my grandchildren will continue to go to school because they have special needs and they need the structure school provides. They don't have to go full time, just enough to help their families cope with their needs. When they aren't in school, they need to get out if the fresh air to run around and let off energy but that is difficult where you have children of different ages. I would appeal the decision not to allow your grandson to attend or, as nurseries aren't closed, at least see if your granddaughter can attend, given the circumstances. Incidentally, my granddaughter doesn't have an EHCP but her school recognise her mental health. I do understand how difficult it can be for a reluctant school attendee but the pressure was off for such children in the last full lockdown as normal lessons did not take place.
I stopped caring for my grandson during the first lockdown because I am trying to balance looking after me as I am diabetic, my mother who is extremely vulnerable and my daughter who is disabled. I felt terribly guilty but it has been very good for him to spend more time with his parents who were working very long hours before all this started.
If you don't want to stop helping your daughter with childcare, perhaps you could just look after one of the children at a time for an hour or two outside where they can run around and you can reduce the risk.
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