My oldest DD is in her 40's but has mental health problems and was advised not to have children because of the heavy medication. I honestly doubt she would have done anyway as she is usually single and very selfish.
My youngest, single, DD always said she didn't want children, but when she had pelvic infections and found that she couldn't, she changed her mind. Since then she has adopted and it is hard work, for her and for us!
My oldest son is single and unlikely to have children.
I'm lucky that my second son has children but it is always their choice, their lives are the ones that would be changed the most.
I don't know the situation of your DC Enidd so don't know if this is a decision they have made or just circumstances, but would say that it is best for you to live your life and make the most of everything that comes your way. Once your grandchildren are adults you often don't see much of them so you need a full life of your own either way.
Please don't be disappointed in your life, it crushes you.