I came off hrt after 3years as I got scared as my mum got breast cancer due to them estrogen dominance of the hrt. It was for a year but was a year from hell. Panic and anxiety attack’s were horrendous, not sleeping, and then told i had developed fibromyalgia, the joint pains were terrible,because I was having no quality of life at 54 doc advised me to go back on. All I can say is they give me my life back. Actually worth taking the risk. In that year I tried just about every different remedy, alternative treatments which I believe in but nothing would work. Only hrt. Dont really want to be on synthetic hormones but cannot are away out of it.