I know of a family in which their is a filial history of a degenerative wasting disease, with resulting blindness and very premature death. They knew this when they had their first child, hoping that he/she would not be afflicted. Sadly he is and now, at aged 9, he is completely blind, immobile and is not expected to live beyond 10 years of age. They've gone on to have 3 more children, all of whom have the same terrible disease and are all in various stages of blindness and immobility. The community has held many fund raising events so that they can have as much practical support as is possible and, whilst I have also contributed to that, I have wondered why, having seen the devastating effects of this illness, they have risked the lives and well being of 4 very young children. But I'm not in their shoes and so I don't know the answer.