“They will get accommodation and support while the Rwandan government considers their application, and if they are successful they can stay in the east African country with up to five years' access to education and support.
If their asylum claim is unsuccessful, they will be offered the chance to apply for other immigration routes, but could face deportation from Rwanda.
The letter, signed by the entire senior leadership of the Church of England, said those being sent to Rwanda have had no chance to reunite with family in Britain.
"Many are desperate people fleeing unspeakable horrors. These are people Jesus had in mind as he said when we offer hospitality to a stranger, we do it for him," it says.
"We cannot offer asylum to everyone, but we must not outsource our ethical responsibilities, or discard international law - which protects the right to claim asylum."