Difficult to begin, but my DS of 43 and his wife have not spoken to me or our family for almost 4 years and I don't anticipate in the foreseeable future, they ever will. I am desperately sad that I don't see him and despite after a confrontation with his wife, I tried to call and email, but all attempts were rebuffed. I had known for a number of years that she had a problem of jealousy with my DD who is 4 years younger than her brother, forever niggling me with negative comments about her until eventually I noticed my DS doing the same to me. I love my DS dearly and yet I constantly defended my DD, knowing she would be horrified if she knew what they were saying about her. It culminated 4 years ago, in my DIL coming to my place of work and informing me that my son had cancer. I was terribly upset to hear the news and tried to ask her questions about his treatment and how he was, instead I heard a barrage of nasty comments about my DD. I was distraught and asked her to leave as I couldn't listen to this anymore. Within minutes I heard from my son that I had upset his wife and they no longer wished to speak to me or my daughter. I tried to protest that I was terribly concerned about his illness and would give a few days cooling off period, but it needed to be discussed. He or she never spoke again to us. My daughters attitude has changes from upset to anger as she is a good person and doesn't know where all thus has come from. We always thought DIL was a lovely girl, who occasionally became very emotional. We empathised with her and was always supportive. I was the only person invited to their wedding, alongside DILS mother, who was a lovely person too. He cut off contact with a lot of his friends and all family, so we were the last to be cut out of their lives. Sorry about this long letter, it's the first time I've written it down. I find it difficult to sleep and think of him constantly but have tried to move on. I don't know where they live now, so do you think it's wise to let him go?