I understand why you are worried, but quite honestly it is a case of the least said, soonest mended.
If my arthimetic is correct and I have understood you correctly, your son married, at the age of 22, a girl he had known since he was 16,.Presumably, she was about the same age.
Marrying relatively early, they have done well to stay together for 22 years.
Even if your youngest grandchildren are still small, there is nothing you can or should do, except to keep on as good terms as possible with your former DIL, your grandchildren and your son, and try to establish a good relationship with his girlfriend.
My greatest concern would be her age, if the friendship lasts and they marry. She is the age where she might well want children, while you son may not be anxious for a second family.
However, that cannot be your or my concern either. A woman of 24 who falls for a man nearly twice her age, and one who has four children already, should have considered this, and we do not know that she does want children. It could be that your son's age and status as a father attracts her because she has no desire for children.
Your grandchildren should be mature enough to be happy if their father is happy. If they aren't, you will need to try to address that problem. They assuredly know plenty of others their own ages whose parents have split up and where one or both have formed a new realationship, so they may not be particularly worried about this.