I'm over 50 and I've lost 55lbs so it is possible.
In my experience, the hot flushes can actually help your weight loss efforts (a bit anyway). Because, when you have a hot flush or night sweats, your body temperature rises. And when your body has to work to change your body temperature, either up or down, it uses up energy. The result is that you burn a few more calories! This is good news if you’re trying to lose weight and you’re over 50 or in the menopause or peri menopause.
I definitely noticed that when I hit my late forties and then the big 50, my metabolism slowed down. While it did take almost a year before I saw a difference, I found a way to speed up my metabolism. And I now benefit from a metabolism which I think is equal to how it was ten years ago.
My Energy levels dropped too, but walking a lot helped me get them back up. Not sure if it's okay to post a link to my blog here. Please remove if not, but I wrote an article on this exact subject which might be useful Losing weight after 50